Once the key components have been identified, it is recommended to review available information and identify gaps in knowledge compared to the critical hazard assessment parameters listed in Table 1. It is advisable to start by listing all relevant process materials (e.g., raw materials, intermediates, products, catalysts, solvents, by-products, off-gases). The first step in identifying chemical hazards involves literature searches and theoretical estimations. Table 1 – Key Components for Hazard AssessmentĪt the discovery stage of a project, it is essential to identify any compounds or intermediates that possess explosive properties and recognize the burden that would be placed on the lab and/or further scale-up production. Examples of critical parameters that should be considered when developing a safe process are listed in Table 1. It is crucial to identify glaring reactive hazards to ensure production is feasible. ![]() This step in the process typically involves a combination of desktop screening and small-scale testing. When a new chemical (or new to your facility) is targeted for production, the first critical step for developing an inherently safe process is identifying primary chemical hazards. Scale: Typically, on the lab scale up to potentially pilot or kilo plant scale ![]() Goal: Identify target material and start development of a synthetic route for manufacturing The level of detail spent analyzing any given parameter needs to be commensurate with the level of risk and hazard level. It is important to note that every process is different. This article provides recommendations for consideration at any step in production, from discovery to commercialization. It is essential to consider the presence of hazards throughout the various developmental stages or scale of production.
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